How Does Synadrene Work?

The Synedrex New Formula!

Are you missing Synedrex? Well you no longer have to wait for their replacement product to come out! Hi Tech Pharmaceuticals has released Synadrene, which is identical to the original Synedrex from years ago, yes…the one with DMHA Pills is back! If you like the results you got from Metabolic Nutrition Synedrex, then you are going to love this product. It goes above and replaces the AMP Citrate with DMHA Pills, which is a much stronger and effective stimulant. But everything else is the same.

History of Synedrex

How Does Synadrene Work? • Original: Synedrex becomes very popular due to DMAA Pills
• 2nd Version: Metabolic Nutrition removes DMAA and stacks it with more caffeine
• 3rd Version: Metabolic replaces the abundance of caffeine with AMP Citrate and now is discontinued
• 4th Version: Hi-Tech comes out with Synadrene a replacement and better version of the past Synedrex

So, as you can see with Synadrene, you are getting the same formula as the original from years ago.

Who Should Take Synadrene by Hi-Tech Pharmaceuticals?

This product is for anyone looking to lose weight, suppress their appetite or increase energy throughout the day. Whether you are on a diet or looking for something to take before your workout, this product is perfect. It can be taken by men or women, at the same dose, so it’s perfect no matter what fitness level you are at. Now because of the potency it should not be taken with other stimulants, but still can be stacked with certain products.

Benefits & Results

• Increased Fat Loss
• Suppressed Appetite
• All Day Energy
• Improved Feelings of Well Being & Mood

What’s in Synadrene that makes it WORK?

Synadrene Proprietary Blend (815mg)


The hallmark ingredient of all stim-based products, methylxanthine, the most famous of these being of course caffeine. Methylxanthines are potent stimulators of the CNS that antagonize all types of adenosine receptors. It’s via this biological action that many of caffeine’s well known effects (increased energy, alertness, and performance) can be attributed to.

We’re not sure how much is in here, but being listed first in the prop blend, you can rest assured there’s a considerable amount packed in here. We’ll reach out to Hi-Tech and see what we can squeeze out of them in regards to amounts.

Green Tea Extract

The benefits of Green Tea extract can hardly be debated as it’s been pretty well established to be beneficial for the cardiovascular system. Green tea’s ergogenic and “healthy-ifying” traits are due in large part to its high polyphenol and catechin content, the most prominent catechin being EGCG.

There’s more to EGCG, short for Epigallocatechin gallate, than just cardiovascular system support though. It’s also been shown to induce lipolysis, and when combined with caffeine, these effects are even further amplified, as it is here.

Hi-Tech has now gone on the record and stated that they’ve used a standardized Green Tea with 45% EGCg / 75% total catechins / 95% polyphenols.

DMHA    (Dimethylhexylamine)

Those of you familiar with Hi-Tech’s vast array of fat burners have no doubt encountered DMHA in some form or another during your supplementation days. But, just as a quick refresher,  DMHA, also commonly known as Octodrine and scientifically named Dimethylhexylamine or 2-aminoisoheptane, is a psychoactive central nervous system stimulant with a similar molecular structure to a number of illegal stimulants including AMP Citrate (DMBA), Ephedrine.

As a powerful CNS stimulant, DMHA triggers the release of norepinephrine in the body. This gives users an incredible feel-good sensation unlike anything they’ve used before, or since really.

Anecdotally, DMHA is also said to provide tremendous amounts of appetite suppression as well – although there’s no quantifiable research results to prove this conclusively.


Sulbutiamine is a synthetic derivative of Thiamine well-known for its ability to offset fatigue as well as improve cognition and memory. This novel form of thiamine was originally created by a group of Japanese scientists who bonded 2 thiamine molecules with a sulphur group.

The reason for using this synthetic variation of Thiamine, is that the organic version doesn’t cross the blood-brain barrier all that easily. However, Sulbutiamine has an increased fat-solubility compared to Thiamin, which allows it to easily cross the barrier. From here, it can then increase circulating levels of thiamine in the body.

The main reason it’s included in a fat burner, is that it helps combat brain fog, a “side effect” of being on low calories and dieting for prolonged periods of time. One of the several reasons why Synedrex stood out – and why Synadrene will continue to stand out!

Sandalwood Extract

Sandalwood is a type of tree indigenous to India that yields an incredibly fragrant timber and oil. It’s traditionally been used for a wide number of ailments included cold/flu remedies, anxiety, muscle cramping, and GI distress.
From a weight loss perspective, sandalwood has exhibited various anti-diabetic properties. Additionally, it also helps improve memory, compounding off the anti-brain fog benefits we mentioned above.

This is a rare area of focus for fat burners, but it’s nice to see Hi-Tech taking a step in this novel direction to keep one of the most underrated ingredients in Synedrex in this next gen thermogenic.

Yohimbine Extract

So far, we’ve encountered ingredients that either stimulate lipolysis or improve cognition. However, Yohimbine performs a different trick of sorts, it actually prevents the body from storing fat. See, “Y”, as it’s sometimes called, is a strong alpha receptor agonist that inhibits the body’s fat storing mechanisms.

There’s more though, yohimbine also significantly reduces feelings of hunger even more so when taken on an empty stomach.

Much like DMAA and caffeine, we’re not sure how much yohimbine is in Synadrene, so if you’re sensitive to yohimbe / yohimbine, proceed with caution to see how you react.

Alpha Lipoic Acid

Alpha Lipoic Acid (ALA) is a fatty acid located in the mitochondria of every cell in the human body that functions as a cofactor in energy production. ALA also helps regulate glucose and lipid metabolism in the body and improve glycogen storage. This action ultimately reduces blood sugar via ALA’s interactions with GLUT-4 (an important glucose transporter in the body).

Activation of GLUT-4 kicks insulin into action, encouraging glucose uptake by muscles as well as “burning fat for fuel” by muscles.

Just like with sandalwood, Hi-Tech is making use of a rather infrequently used ingredient that really should be included more often. The sandalwood and ALA combo, alongside DMAA of course, are really attributed to being the serious difference-makers compared to the rest of the 1,3 Dimethylamylamine supplements out there.


Poly-Thyronine is a unique combination of thyroid hormone metabolites triiodothyronine (T2). It’s naturally occurring and is involved in virtually all physiological functions.

As for its inclusion in a fat burner, supplementing with thyronine metabolites has been shown to elevate metabolic rate and reduce appetite without adversely affecting your heart rate, blood pressure, or any other effect stimulants would affect in the body!

It’s also worth mentioning that these same studies also showed decrease in overall body weight and no cardiac side effects observed whatsoever!

So, if you were a fan of Synedrex, fear not – it’s back, just from a different (and highly-trusted) brand and with a different name. This is what you need to try next Synadrene Today.

Synadrene Ingredients

Synadrene Dosage:

Take 1 capsule up to 3 times daily – but we’re finding that one capsule in the morning and one capsule after lunch. Do not exceed 4 capsules in any 24-hour period.

Typically, that first capsule is best taken on an empty stomach 15-30 minutes before breakfast, so you can let the appetite suppressants kick in and keep your eating under control!

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